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Biased agonism and polymorphic variation at the GLP-1 receptor:  Implications for the development of personalised therapeutics -  ScienceDirect
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4.2 ★★★★★
Based on 1853 reviews
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Steve just Steve
Birmingham, US
★★★★★ 5
Good grip glow ball
Style: Recharges, Size: Medium
Love this glow in the dark Chuck IT. Get a black light flashlight to charge the neon instantly. Good texture gives the dog better grip than the smooth all white glow in the dark chuck it balls.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 9, 2026
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Verified Purchase
Madison Burk
Dallas, US
★★★★★ 5
Great treat replacing for motivated dogs!!!
Color: Yellow
i use this ball strictly for training purposes with my Aussie who is super obsessed with balls. My dog seriously loves this ball. This has taken the place of treats. When we aren’t training the ball goes in a closet. So far it’s durable enough for our training session. (If we have a good session he is rewarded with having free access to the ball for a limited time, he enjoys a little tug so I normally hold the rope and let him have at the ball) for $10 id say it’s worth it. It’s definitely not indestructible but it is cheaper for me to replace these than buying treats every week as rewards.
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Reviewed in the United States on January 17, 2026
A
Verified Purchase
Amazon Customer
Massapequa, US
★★★★★ 5
Fun toy
Color: Orange
Well made. The puppies love it, BUT it is too hard for them at an early age ( 2 1/2 months. They ended up grabbing the rope. As they got 5-6 months they were fine. Make another model 1 inch smaller and half as hard Belgian Malinois & Doberman.
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Reviewed in the United States on April 15, 2026
S
Verified Purchase
Schamy
Port Orchard, US
★★★★★ 5
Durable & great deal
Color: Orange and Yellow
My foster German Shepherd has a jaw that's locked and loaded but love these cause I can play tug of war or fling it way across the yard. He's chewed or busted every ball he's received except these. I'm loving them. Very durable, bounces too really well and I can find it easily with the colors.
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Reviewed in the United States on April 8, 2026
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Verified Purchase
Amy
Draper, US
★★★★★ 4
Small balls and came apart
Color: Orange and Yellow
My dog loves them; these are my first set of this type of toy. Good quality materials, but the knot in the rope came undone and the ball came off in 3days. I had someone fix and re-tie and it has held up so far. The next set I’ll get in a larger size, they’re a tad small for my dog’s mouth.
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Reviewed in the United States on January 11, 2025

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